Novel therapeutic approaches for inclusion body myositis
نویسندگان
چکیده
منابع مشابه
Inclusion body myositis: therapeutic approaches
Correspondence: Rohit Aggarwal UPMC Arthritis and Autoimmunity Clinic, Department of Medicine, Rheumatology, University of Pittsburgh, Falk Medical Building, 3601 Fifth Avenue, Suite 2B, Pittsburgh, PA 15213, USA Tel +1 412 648 9782 Fax +1 412 383 8864 Email [email protected] Abstract: The idiopathic inflammatory myopathies are a heterogeneous group of diseases that include dermatomyositis (DM...
متن کاملEmerging therapeutic options for sporadic inclusion body myositis.
Sporadic inclusion body myositis is the most common inflammatory muscle disorder preferentially affecting males over the age of 40 years. Progressive muscle weakness of the finger flexors and quadriceps muscles results in loss of independence with activities of daily living and eventual wheelchair dependence. Initial signs of disease are often overlooked and can lead to mis- or delayed diagnosi...
متن کاملInclusion-body myositis
Inclusion-body myositis is the most frequent and disabling myopathy seen in patients over 50 years of age. The distinct clinical features that lead to correct diagnosis and inclusion-body myositis mimics are highlighted. Inclusionbody myositis has a complex pathogenesis in which autoimmune and inflammatory features coexist with elements of degeneration and abundant accumulations of various stre...
متن کاملInclusion Body Myositis
Inclusion body myositis is an insidious, slowly progressive myopathy of middle-aged and older individuals. Because of these characteristics, diagnosis is often delayed. Affected muscle is marked by the presence of rimmed vacuoles, inclusions, and an inflammatory infiltrate largely made up of CD8 T lymphocytes and macrophages. The inclusions contain beta-amyloid and phosphorylated tau protein, a...
متن کاملInclusion body myositis.
The histochemical and ultrastructural study of muscle biopsies of two patients with a chronic muscle weakness and wasting showed particular changes in muscle fibers: (1) peripheral lined vacuoles, containing whorls of membranes and cytoplasmic debris; (2) collections of intranuclear and intrasarcoplasmic tubular filaments (16-18 nm in external diameter and 6.5 nm in inner diameter). These chang...
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ژورنال
عنوان ژورنال: Current Opinion in Rheumatology
سال: 2010
ISSN: 1040-8711
DOI: 10.1097/bor.0b013e32833f0f4a